Redox Signaling Science

Why Do You Need ASEA?

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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ASEA Science Advisory Council

 

 

Prepared by: Gary Samuelson, Ph.D. Robertson D. Ward, M.D., FAAFP David Carpenter, N.D., C.Ac., C.C.I.

The North Carolina Research Campus, and the Appalachian State University Human Performance Laboratory, under the direction of Dr. David Nieman’s world renowned team of scientists, uncovered new findings proving that the consumption of ASEA empowers humans to shift the availability of free fatty acids. These calorie sources represent a more favorable and efficient source of fuel for exercise and all daily life activity.

Facts about Our Metabolism

Cells inside our body breathe! The processes of metabolism at a cellular level involves the consumption of molecular oxygen and large molecule energy sources (sugar, glycogen, fatty acids, and amino acids). Through the process of oxidative phosphorylation (cellular respiration…breathing!) the cells create energy (ATP). The mitochondria in our cells do this work, and this is where Redox Signaling molecules are created.

Metabolism and Athletes

We understand that our cells always strive to run at the greatest efficiency possible. Through the conditioning of our bodies, our cells learn to use certain fuel sources preferentially. We are all familiar with the fatigue and pain that happens after rigorously exercising out-of-shape muscle groups. This happens because the muscle exhausts the standard glycogen source for fuel and then shifts to anaerobic metabolism (using fuel without oxygen), which forms lactic acid metabolites. But trained distance runners have conditioned their bodies to utilize a different fuel source: fatty acids (which are 6 times more energy-providing than other sources). By using fatty acids, these athletes preserve their muscle glycogen stores for strenuous bursts, like at the end of races, and that means greater endurance.

This is important. Endurance athletes actually condition their bodies to use fatty acids as a preferred fuel source, sparing muscle glycogen and increasing endurance.

Specific Metabolite Research Findings with ASEA:

The astonishing results of this randomized, double-blinded, crossover, placebo-based research showed that after one week of drinking 4 ounces of ASEA daily, the test subjects demonstrated a shift in 43 of 108 metabolites measured from the blood sample. These shifts were revealed using ultra-sensitive mass-spectroscopic measurement techniques. These shifts were so great that it was thought that there might be a software anomaly and scientists requested a manual inspection to verify data.

The largest metabolite shifts were in serum fatty acids. Again, these shifts happened after one week of consumption and before any athletic activity. Fatty acids are typically mobilized from abdominal body fat stores. They included myristic acid, palmitic acid, oleic acid, stearic acid, palmitelaidic acid, and capric acid. Don’t let the “acid” part throw you off; these are sources of fuel for the human body.

The chemical markers of these fatty acids are called “metabolites,” and their various concentrations in our blood represent a fingerprint of our metabolic balance. The metabolite shifts found due to ASEA ingestion are profound and very beneficial to health, since these shifts mimic what the body does when seeking fuel efficiency; that is, using fatty acids as a preferred fuel source and sparing muscle glycogen.

These important metabolite changes have resulted in applications for new patents for ASEA, and have prompted further studies at the North Carolina Research Campus. Additionally, all of these changes occurred without any evidence of toxicity whatsoever on any basic organ functions in liver and kidney tissue.

Conclusions

These initial results from a larger study on athletic performance have demonstrated that ASEA, which is composed of Redox Signaling molecules, has a profound impact on mobilization of fatty acids as they aid with efficiency in cellular respiration. This favorable pattern of increased availability of fatty acids for fuel consumption represents a foundational shift in our metabolic fingerprint – a shift toward more effective patterns of fuel usage and energy output.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

ASEA athletes are finding they can go farther, faster, longer without red-lining their heart rate or going into critical oxygen debt

  • Redox Signaling molecules are the key to cell efficiency
  • ASEA athletes increase cell efficiency, giving them a competitive advantage
  • Clinical studies show 12% average increase in time to VT (ventilatory threshold)
  • Tested athletes report shorter recovery time and less soreness and fatigue
  • Clinically proven, 100% safe, completely free of banned substances

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View the FAQ for the ASEA Frontiers: Metabolites Research

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

Q. Who conducted this research?

(Want a full 20 page Summary of the Research?  Get it Here!)

A. This research took place at the North Carolina Research Institute, a collaborative entity involving seven universities (Duke, UNC Chapel Hill, NC State, UNC Charlotte, NC Central, NC A&T State, UNC Greensboro, Appalachian State). The research was led by the Appalachian State University’s Human Performance Laboratory under the direction of Dr. David Nieman. Dr. Nieman and his team of Ph.Ds. are renowned for their rigorous research into the effects of supplementation on exercise and exertion.

Q. How was the research conducted?

A. The research team selected 20 highly fit cyclists, then randomized them into two groups of 10. Using doubleblinded techniques in which neither the athletes nor the researchers knew which group received ASEA and which received a placebo, one group drank four ounces of ASEA each day for seven days, while the other drank equal amounts of placebo. At the end of seven days, both groups undertook a 75-km cycling trial. Blood was drawn immediately before the trial, immediately after, and one hour after.  After a washout period in which the athletes drank neither ASEA nor placebo, the crossover portion of the research took place. Again double-blinded, the original ASEA group now drank the placebo for seven days, and the original placebo group drank ASEA. At the end of the seven days, both groups did the same 75-km cycling trial, and blood was drawn just as before.

Q. What was used as a placebo?

A. The answer to this question is extremely enlightening, especially if you’ve ever heard someone say that ASEA is just salt water. In the research that was conducted by the Human Performance Laboratory, the placebo was salt water! In other words, the research compared ASEA to salt water and found significant and substantial differences, so there is no way anyone can ever say that ASEA is simply salt water.

Q. What were the results of the research?

A. The researchers expected to see some difference in metabolite shift between ASEA and the placebo. However, they expected to see those shifts AFTER exercise, since most researched supplements express metabolite shifts due to the combination of supplement and exercise. To their surprise, they found that athletes who drank ASEA experienced a significant shift in metabolites PRIOR to exercise. In total, researchers found a shift in 43 metabolites simply from drinking ASEA, even before they began to cycle. The results were so extraordinary that Dr. Neiman said, “When I saw it, I couldn’t believe it.”

Q. What are metabolites?

A. Metabolism is the name we give to the chemical reactions that take place inside our cells in order to sustain life. Metabolites are the molecules that participate in our metabolism cycles. They are very small molecules in the blood that shift in response to supplementation and/or exercise. Metabolomics, the study of these metabolite shifts, is the very latest tool used by researchers to understand what effects supplementation has in the human body.

Q. Why was this shift in metabolites so surprising to the researchers?

A. In this research, 108 metabolites were mapped, and so the first thing that caught the scientists off guard was that a shift in 43 metabolites represented about 40% of the total. When you consider that most supplements may shift 10-20 metabolites, the sheer number of shifts was enough to get the researchers’ attention. But even more surprising, these shifts occurred PRIOR to exercise. Most supplements tested by the Human Performance Lab express metabolite shifts AFTER exercise. In other words, most supplements cause metabolite shifts when combined with exercise. ASEA, on the other hand, caused a major shift in metabolites even before the athletes began cycling. Simply drinking ASEA caused these shifts.

Q. What do these metabolite shifts mean?

A. The specific metabolite shifts in the athletes who drank ASEA pointed mostly to a vast mobilization of free fatty acids. Fatty acids are the main source of fuel for the body, and they mostly come from fat stores in the body known as adipose tissue.

Q. Free fatty acids? Why is that significant?

A. When anyone, athlete or not, begins to exercise, the muscles need fuel. Initially, the fuel source for this physical effort is blood glucose and muscle glycogen. When muscle glycogen is depleted, the body shifts to another source of fuel: fatty acids from adipose tissue. The body converts triglycerides in adipose tissue into free fatty acids, which “mobilizes” those fatty acids – puts them in the blood stream for the muscles to use as fuel. What makes the research results so surprising is that even before exercise – before using muscle glycogen to the point of depletion – fatty acids are mobilized and ready
to use as fuel for the muscles. The body is being “primed for exercise,” as one Ph.D. on the research team put it.

Q. What effect does this have on muscle glycogen?

A. The implication is that muscle glycogen is likely being spared by drinking ASEA. While further research is being done to confirm this, the ramifications are huge. Athletes take months to train their bodies to spare glycogen and use fatty acids as fuel. And here it appears to be happening simply from drinking ASEA.

Q. What if I’m not an athlete? Does this research mean anything for me?

A. The mobilization of free fatty acids is incredible news for athletes, but it also has meaning for the rest of us, as well. Once these fatty acids are mobilized, they will be used by the body as fuel. They are the primary fuel source for a body at rest. The body needs fuel simply to stay alive, so the freed-up fatty acids will be burned no matter what.

Q. Does this make ASEA a weight-loss product?

A. It is wrong to think of ASEA as a weight-loss product. Exercise is a weight-loss product. Proper nutrition is a weight-loss product. But that said, one very clear conclusion coming from the research is this: If you want to burn more fat during exercise, drink ASEA.

Q. I understand that the research also indicated an increase in ascorbic acid. What does that mean?

A. The research did show a spike in the body’s production of ascorbic acid post-exercise, but it’s simply too early to draw any conclusions about what this means. Further research will be done to learn more

Q. How does Redox Signaling tie into this research?

A. Redox Signaling works on a cellular level, and its primary functions ensure the ongoing vitality of our cells, including proper cell metabolism. Metabolites are the “fingerprints” left behind during cell metabolism, an indication of the chemical reactions that take place inside the cell. This research helps reveal some of the effects of the world’s first and only Redox Signaling supplement on cell metabolism.

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ASEA Science

by Matt

More than 16 years ago, a group of medical professionals, engineers, and researchers discovered a proprietary method for creating Redox Signaling molecules native to the human body. This work led to the creation of the foundational technology behind ASEA, providing a way to deliver to the body these stabilized Redox Signaling molecules necessary for optimal cellular health.

Building on this foundational technology, ASEA scientists and researchers improved and expanded the proprietary process, further stabilizing these Redox Signaling molecules and making them commercially available to consumers. Since the introduction of ASEA into the marketplace, these scientists have continued to study the beneficial effects of ASEA on the cells, tissues, and organs of the body.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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Scientist

Volumes of research from independent scientists around the world confirm the vital nature of Redox Signaling to cell health. And every day more research and published articles are appearing about Redox Signaling, making it one of the fastest growing research fields in science.

ASEA is the first and only stable, perfectly balanced mixture of these Redox Signaling reactive molecules that exists outside of living cells, and can be used to help maintain proper balance inside the body to support the immune system and healing process.

Redox Signaling Research Links:

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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ASEA BookmarkA monumental announcement was made today at the ASEA Italy Grand Opening event.  Jarom Webb, ASEA COO, announced the opening of the Netherlands market and the launch of the Netherlands Distant Selling Program.  Under this new program, ASEA product can be legally purchased and received through the Netherlands in six additional European markets: Germany, Spain, France, UK, Ireland, and Slovenia.  ASEA product will be shipped out of our distribution center in the Netherlands, and commissions will now be paid in these markets under the global compensation plan.

If you are looking to try ASEA or are Interested in Joining our ASEA team please contact us.  We are independent Associates led by Triple Diamond Nancy Norton Thunell.  Nancy was the first Associate in ASEA, a member of the founders club, a member of the Diamond founders club and Daughter of the CEO Verdis Norton.  Our team has a very close and personal connection to this product and this company.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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Report for ASEA on Experimental Results – In Vitro
Antioxidant Enhancement and Oxidative Stress Reduction

MoleculePurpose:


This document reports to ASEA the results of the in vitro tests run from February to March, 2009. Live cells in culture dishes were exposed to ASEA and the bioactivity regarding antioxidant activity of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) as well as the increase in the native production of these antioxidants inside cells was measured. In addition, tests were run to determine if oxidative stress was reduced in the cells and that cell viability was enhanced by exposure to ASEA.

Experimental Methods for Antioxidant Activity:


Cells were cultured in several dishes with a bovine serum growth medium. As a primary measure, mouse epithelial-like cells were cultured (these cells react similarly to human cells) and later human endothelial cells were used to obtain relevant quantitative results.

In the antioxidant enhancement tests, some of the cell cultures were exposed to ASEA and others cultures to the same amount of an inert phosphate buffered saline solution (PBS). The antioxidant activity of the cells in each was measured by a purchased kit, Array Design Stressgen kit (#900-158 for GPx activity and #900-157 for SOD activity). The chemical reagents inside these kits measure the ability of the antioxidants in the cell extracts to reduce oxidant activity that occurs naturally when certain oxidizing biological chemicals are added.

Due to the fact that some of the reactive molecules in ASEA might react and interfere with some of the chemical agents in these kits, several preliminary experiments were done to examine the accuracy of the results based against known standards of antioxidant activity and adjustments were made.

Results of Antioxidant Activity Tests:

The first results obtained showed large, well-defined effects. The cell extracts exposed to ASEA exhibited eight (8) times the antioxidant efficiency for GPx that those exposed to the inert PBS. The SOD antioxidant efficiency was slightly less, with about 5 times enhancements in efficiency. Of note, this efficiency was evident especially at low level concentrations of ASEA, tested down to 2.5% of full strength. Increasing the concentration of ASEA at high concentrations did not notably increase the antioxidant efficiency; thus there appears to be a very low saturation threshold at low concentrations of GPx. More experimentation would need to be done at very low concentrations of ASEA in order to understand the concentration dependence fully.

It is safe to say that at least a 500% improvement in the overall antioxidant efficiency was seen during these preliminary in vitro tests due to ASEA exposure.

Experimental Methods for Antioxidant Up-regulation:

In these experiments, some cultured human endothelial cells were exposed to ASEA and others only to an inert phosphate buffer solution (PBS). Standard Western Blot analysis on all cells was done to determine if exposure to ASEA activated the nucleus to call for increased production of antioxidants, such as GPx. The concentrations of transcription factors (messengers) in the nucleus that call for up-regulation of antioxidants were also measured in human endothelial cells and compared to cells that had not been exposed to ASEA.

The movement of the transcription factors into the nucleus can be seen with certain dyes under a microscope and thus offers a way to see the call for up-regulation of antioxidants without some of the obstacles presented by the use of endothelial cells.

Since the production of antioxidants can also be up-regulated by exposure of the cells to certain low levels of inflammatory toxins, tests were done to make sure that ASEA was not provoking the cells to undergo this low-level inflammatory or toxic response.

Results for Antioxidant Up-Regulation

The results for these tests were extraordinary in several regards. First, there was a real up-regulation of anti-oxidant production in cells exposed to ASEA. This effect was temporary, lasting only about 120 minutes but was clearly visible. The most interesting result, however, is that exposure to ASEA at any concentration did not invoke the normal inflammatory transcription factor (NF-kappaB) and yet did invoke the antioxidant transcription factor (NRF2). Stimulating the production of antioxidants without stimulation of low-level inflammation is very rare and has stirred some interest in the scientific community.

The tests that measured the movement of transcription factors were controlled tests, they had “positive controls” that showed the test was working. For example, a small amount of a toxin that is known to cause the inflammatory response (movement of the NF-kappaB transcription factor) was tested side by side with the ASEA, a positive response was very clearly seen with the toxin and no response was seen with ASEA. With the antioxidant up-regulation transcription factor NRF2, positive movement of this transcription factor was seen in both ASEA and in the positive control. Hundreds of cells were observed in order to obtain these results.

These results were also verified by the Western Blot analysis showing clear responses in the increase of antioxidants upon exposure to ASEA relative to the saline control.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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Click to Play the ASEA Science Presentation

ASEA Science Presentation (Click the Slide to start the Presentation) or if you want the extended ASEA Science presentation for Medical Professionals click Here

The Human body is made up of approximately 75 trillion cells

  1. The cell
  2. When cells get damaged
  3. The last 30 years (how have we done?)
  4. The next 30+ years (what we can do now)
  5. Glutathione (a natural antioxidant)

Each cell in your body has at least one mitochondria, some cells have more than 10,000 mitochondria.  The cell takes in nutrients and in the Krebs cycle produces ATP (Energy).  This process also creates Redox Signaling Molecules.

Until recently scientist thought that the Redox Signaling molecules were an unfortunate side effect to the krebs cycle.  Today we are starting to understand that those molecules are critical to life, cellular communication and health.

All health problems can be linked to damaged cells.  Oxidative stress is known to be a primary if not leading contributor to over 200 health challenges.

How do we combat oxidative stress?  Antioxidants! The last 30 years we have been told to get our antioxidants from plants.  What about native to the body antioxidants like glutathione?   Your native antioxidants are much more effective at taking out free radicals in the body!

Plant based antioxidants can eliminate a free radical at a 1:1 ratio.  Natural antioxidants can eliminate free radicals at at 70,000,000:1 ratio per second.

 

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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As seen on American Health Journal Dr. Gary Samuelson discusses how our cells communicate.

 

 

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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As seen on American Health Journal, Dr. Gary Samuelson and Dr. Robertson Ward discuss how our cells heal themselves and Redox Signaling

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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RobPattyWardIn January of 2010, a good friend of Dr. Robertson Ward sent him a case of ASEA. He and his wife, Patty, were out of town for the weekend and the product sat freezing on their front doorstep for two days.  Winter in Kentucky can be bitter cold. When they returned from their trip and brought the product into the house it was frozen rock-solid. After opening the product and reviewing the instruction sheet they learned that ASEA is not sensitive to extreme heat or cold. If the product arrives froze, it simply needs to that completely before use.

Dr. Ward was more than a little bit intrigued by this information. Shelf-stable Redox Signaling molecules in a bottle! It was then that he decided to look into the science behind the product and be his own case study. He began reading Dr. Gary Samuelson’s book The Science of Healing Revealed and found that he was “enchanted with the real science,” the molecular biology that he, as a physician, could really relate to.

When the product finally thawed, Dr. Ward and his wife tried it. He knew immediately that it tasted just like it should. “If you were able to take a cell from your body and squeeze it like a lemon into a glass, it would taste just like ASEA!” Since that first day, Dr. Ward and his wife have unfailingly taken their ASEA every day.  both have been enjoying better sleep patterns and a significant increase in energy. In fact, Dr. Ward is back to running marathons.  Along with enjoying some of the best races of his life, he has found his recovery to be almost immediate! “I got up the day after the marathon, got out of bed, and I danced a jig in the kitchen. I was so thrilled at how good I felt!”

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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RobWardWhat information can you give on the human brain?

I have an incredible respect for how our brain works. Our brain cells are different and more complicated that any other cell in our body. They have the challenging job of maintaining balance while still completing the necessary regeneration, replication, and repair that all cells must go through.

What can happen when the brain is thrown off balance?

Imbalances can cause mood changes, appetite surges or declines, and sleep disorders. The chemical balance in the brain is crucial. Anyone can be susceptible to an imbalance,  However, the indications are not apparent until the brain is out of balance.

What can we do to support the health of the cells in our brain?

Brain health begins at the cellular level and at its core is the simple but fundamental role of Redox Signaling molecules. These molecules help to clean up the cellular environment. Our brain cells burn a lot of fuel and oxygen, creating oxidative stress which can trigger brain imbalances. In order for our brain to process information, think clearly, and perform to its utmost capability we need to keep the cellular environment as clean and healthy as possible.

Dr. Robertson Ward is an acclaimed Community Medicine physician and researcher. He was awarded a medical degree from the university of Illinois, named University of Cincinnati Family Practice Resident of the Year, and has served with the distinction in top positions as a family practitioner in community health organizations and hospitals all over the mid-west. Dr. Ward has directed over 15 full clinical research studies on hypertension, endocrine/metabolism, infectious diseases, insomnia, musculoskeletal disorders, osteoarthritis, fibromyalgia, and many more.  He has an incredibly broad range of experience in clinical medicine, as well as a proven track record and intense interest in helping people find real solutions to their health problems.

ASEA and its foundational technology are completely protected by U.S. patents 5,334,3835,507,9325,674,5375,731,0086,007,6866,117,285.

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Click the Play button below to listen to Dr. Carpenter discuss the role of the digestive system in the body and how Redox Signaling is vital to digestive system function. He will address the following topics:

  • The important role of the digestive system in the body
  • How the digestive system is the first line of defense for the immune system
  • The critical role of Redox Signaling to proper digestive system function
  • Practical steps for encouraging a healthy digestive system

Learn More About ASEA

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ASEA is a non-toxic, perfectly balanced mixture of Redox Signaling molecules, similar to those constantly produced by all living healthy cells. ASEA enhances and activates the native antioxidants needed to protect and detoxify the cells and at the same time supplements the signaling molecules needed to repair or replace damaged cells and restore healthy tissue and immune function.

If you are intrigued but not convinced, try ASEA™. The corporation offers a full 30-day empty bottle money back guarantee.

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Click the Play button below to listen to Dr. Samuelson and Dr. Ward discuss the role of the cardiovascular system in the body and how Redox Signaling helps the cardiovascular system to function properly. They address the following topics:

  • The importance of a healthy cardiovascular system to overall health
  • How the cardiovascular system acts as the “roadway” of the body
  • How Redox Signaling molecules are essential to the proper function of the cardiovascular system
  • How Redox Signaling molecules enable the cardiovascular system to immediately react to damage

Learn More About ASEA

Contact Matt

ASEA is a non-toxic, perfectly balanced mixture of Redox Signaling molecules, similar to those constantly produced by all living healthy cells. ASEA enhances and activates the native antioxidants needed to protect and detoxify the cells and at the same time supplements the signaling molecules needed to repair or replace damaged cells and restore healthy tissue and immune function.

If you are intrigued but not convinced, try ASEA™. The corporation offers a full 30-day empty bottle money back guarantee.

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